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KMID : 1161420220250100943
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Journal of Medicinal Food
2022 Volume.25 No. 10 p.943 ~ p.951
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The Aqueous Extract of Humulus japonicus Ameliorates Cognitive Dysfunction in Alzheimer’s Disease Models via Modulating the Cholinergic System
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Kang Chang-Muk
Bang Joon-Seok
Park Seung-Yeon
Jung Tae-Woo
Kim Hyoung-Chun
Chung Yoon-Hee
Jeong Ji-Hoon
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Abstract
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Humulus japonicus (HJ) is an herbal medicine, which has been reported as being antioxidative and anti-inflammatory. The present study aimed to investigate the effect of oral administration of HJ water extract (HJW) on cognitive function through the cholinergic system in Alzheimer’s disease (AD) mouse models. Institute of Cancer Research mice injected with beta-amyloid (Aβ) (1-42) (i.c.v.) and APP/PS1 transgenic (TG) mice were orally administered with HJW at 500?mg/kg/day for 3 weeks. Aβ-injected mice and APP/PS1 TG mice showed cognitive dysfunction, which was evaluated by various behavioral tests. HJW treatment significantly attenuated memory impairments in Aβ-injected mice and APP/PS1 TG mice. Aβ injection decreased acetylcholine (ACh) concentrations and choline acetyltransferase (ChAT) activity, and increased acetylcholinesterase (AChE) activity. These cholinergic impairments were also found in APP/PS1 TG mice. HJW significantly attenuated cholinergic alterations in Aβ-injected mice and TG mice. In addition, HJW significantly decreased Aβ plaque deposition in the cerebral cortex and hippocampus of TG mice. Therefore, the present study demonstrated that HJW protected against AD-related memory impairments via enhancing the cholinergic system and inhibiting Aβ plaque deposition.
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KEYWORD
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Alzheimer’s disease, cholinergic system, cognitive function, Humulus japonicus
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